Hemophilia C in Women
DOI:
https://doi.org/10.5281/zenodo.10096623Keywords:
Factor XI, Rosenthal Syndrome, prolonged bleeding, mutation, fresh frozen plasma FFP, desmopressin, pregnancy, menorrhagiaAbstract
Factor XI (FXI) deficiency (hemophilia C or Rosenthal syndrome) is a genetically-transmitted disease usually inherited in an autosomal recessive pattern associated with genetic defects in the FXI gene. It affects both genders equally, but studies show that the disorder is more common in Ashkenazi Jews. People with hemophilia C do not have spontaneous bleeding, symptoms like uncontrollable or prolonged bleeding, epistaxis, hematuria or bruising occur after serious injuries, major surgeries or after giving birth. In female it may cause menorrhagia. Unless there’s an undergoing surgery or an injury that may cause severe bleeding, people with hemophilia C do not require treatment. Fresh frozen plasma, anticoagulant medication or birth control might reduce the risk of excessive bleeding.1
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